Highlights of prescribing information coadministration of. Abciximab binds to the glycoprotein gp iibiiia receptor of human platelets and inhibits platelet aggregation. Abciximab is intended for use with aspirin and heparin and has been studied only in that setting, as described in clinical studies see package insert. Abciximab binds to the glycoprotein gp iibiiia receptor of human. Highlights of prescribing information for psoriatic. Reopro fda prescribing information, side effects and uses. Full prescribing information 1 indications and usage ocrevus is indicated for the treatment of. In standard animal or human pharmacological tests, betaadrenoreceptor blocking activity of atenolol has been demonstrated by. Taltz is indicated for the treatment of adult patients with active ankylosing spondylitis.
Abciximab inhibits platelet aggregation by preventing. This medication should not be used if you have certain medical conditions. Abciximab indications, dosage, side effects and precautions. Patients received ofirmev 1 g with patientcontrolled analgesia pca morphine or placebo with pca morphine the morning following total hip or knee replacement surgery.
The recommended dose is 160 mg two 80 mg injections at week 0, followed by 80 mg at weeks 2, 4, 6, 8, 10, and 12, then 80 mg every 4 weeks. Because abciximab may increase the risk of bleeding, abciximab is contraindicated in the following clinical situations. Approved drug products containing abciximab listed in the fda orange book. To minimize the risk of bleeding with abciximab, it is important to use weightadjusted dosing of abciximab and lowdose weight adjusted doses of heparin, with adherence to stricter anticoagulation guidelines. Orencia sc allows patients onceweekly selfinjection at home. Abciximab or abcixifiban previously known as c7e3 fab, a glycoprotein iibiiia receptor antagonist manufactured by janssen biologics bv and distributed by eli lilly under the trade name reopro, is a platelet aggregation inhibitor mainly used during and after coronary artery procedures like angioplasty to prevent platelets from sticking together and causing thrombus formation within the. Counsel patients regarding the potentialrisk for mtc with the use of trulicity and inform them of symptoms of thyroid tumors e. Find patient medical information for abciximab intravenous on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Package insert albumin human 5% pdf 265kb supporting documents.
This was a randomized, doubleblind, placebocontrolled, single and repeateddose 24hour study n101. Relapsing forms of multiple sclerosis ms, to include clinically isolated syndrome, relapsingremitting disease, and active secondary progressive disease, in adults primary progressive ms, in adults 2 dosage and administration. Heparin sodium injection, usp is a sterile, nonpyrogenic solution of a highly purified sodium salt of heparin, a high molecular weight polysaccharide derived from porcine intestinal mucosa or beef lung. Abciximab is a chimeric monoclonal antibody that interferes with platelet aggregation by steric hindrance. Easy to read fda package insert, drug facts, dosage and administration, and adverse effects for diamox sequels acetazolamide.
The chimeric 7e3 antibody is produced by continuous perfusion in mammalian cell culture. Discontinue abciximab 48 hours before surgery if possible. Bar codes included on the vial and carton for ease of scanning. It is used mainly during coronary artery procedures such as.
Iv administration of a single bolus doses of abciximab from 0. Ceftazidime for injection, usp sagent pharmaceuticals. Abciximab binds irreversibly to the gpiibiiia receptors and blocks the binding of fibrinogen see fig. Reopro abciximab dose, indications, adverse effects. Tirofiban is a nonpeptide reversible antagonist of the gpiibiiia receptor.
Abciximab abciximab binds to the glycoprotein gp iibiiia receptor of human platelets and inhibits platelet aggregation. Abciximab binds to the intact platelet gpiibiiia receptor, which is a member. Abciximab reduces the chance that a harmful clot will form by preventing certain cells in the blood. Abciximab fda orange book approved drug product list. Target aptt 50 to 70seconds if weight greaterthan or equal to 70kg, 5000unitbolus followed by infusion of unitsh.
Abciximab injection reopro side effects, medical uses. Remove the protective cap from the other end of the transfer. Open the package containing the transfer device by peeling the paper label off the package. Integrilin should be given concomitantly with heparin dosed to achieve the following parameters. Stop continuous infusion of abciximab in patients with failed pcis. Confirm the selection of the correct formulation and strength prior to administration of the drug. Monitor for symptoms such as hypoesthesia, hyperesthesia, paresthesia, discomfort, a burning sensation, neuropathic pain, or weakness. Adjunctive therapy during thrombolysis offlabel safety and efficacy not established. Leiden, the netherlands, a subsidiary of centocor, inc. Transfuse two 8packs of platelets as the patient is coming off pump. Reopro abciximab for intravenous administration description.
Highlights of prescribing information these highlights do not include all the information needed to use taltz safely and effectively. Supporting documents older than three years albumin human related information. Before heparinizing for cp bypass, draw act and give a titrated dose of heparin to obtain act of 400500 seconds. Eptifibatide is a synthetic peptide that binds reversibly to and blocks the gpiibiiia receptor. If weight less than 70kg, 60unitskg bolus followed by infusion of 12unitskgh. Like the ligandmimetic gpiibiiia inhibitors, abciximab causes thrombocytopenia within a. Pharmacodynamics and pharmacokinetics of abciximab. Abciximab blocks the sticking of platelets together and protects the arteries by reducing the formation of thrombus or blood clot. Scribd is the worlds largest social reading and publishing site. Taltz ixekizumab injection, for subcutaneous use initial u. Abciximab is an antiintegrin fab fragment of a human mouse chimeric monoclonal antibody with high affinity and a slow dissociation rate from the gpiibiiia platelet receptor mager et al 2003. Highlights of prescribing information acute ischemic. Learn more about dosing, efficacy, safety and patient financial info for abraxane paclitaxel proteinbound particles for injectable suspension albuminbound.
Abciximab package insert free download as pdf file. Easytoread drug name and dosage strength to aid in identifying the right product. For nonprescription products, read the label or package ingredients carefully. Abciximab can reduce platelet aggregation by more than 90%. The glycoprotein iibiiia receptor inhibitors, abciximab, eptifibatide, and tirofiban, all have similar mechanisms of action to inhibit the platelet aggregation process. Before using abciximab, tell your doctor or pharmacist if you are allergic to it. Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of abciximab in children with use in other age groups. Before using this medicine, consult your doctor or pharmacist if you have.
Integrilin is indicated to decrease the rate of a combined endpoint of death or new myocardial infarction mi in patients with acs unstable angina uanonstelevation myocardial infarction nstemi, including patients who are to be managed medically and those undergoing percutaneous coronary intervention pci. Remove the protective cap from one end of the transfer device and keeping the vial of swfi upright, insert the piercing pin vertically into the center of the stopper of the vial of swfi. Abciximab is a chimeric humanmouse fab fragment that is specific for an epitope on gpiiia close to the fibrinogen recognition site and blocks binding of fibrinogen to the activated integrin 111 chapter 55. Abciximab by injection national library of medicine. Trulicity is contraindicated in patients with a personal or family history of mtc or in patients with men 2. Abciximab is used to lessen the chance of heart attack in people who need percutaneous coronary intervention pci, a procedure to open blocked arteries of the heart a heart attack may occur when a blood vessel in the heart is blocked by a blood clot. Abciximab definition of abciximab by medical dictionary. Abciximab intravenous route before using mayo clinic.